Disease 101

Iron Deficiency Anemia CKD Not On Dialysis

Disease 101
Hypothetical patient portrayals.

What is iron deficiency anemia in
chronic kidney disease (CKD)?

A common condition that occurs when your body doesn't have enough iron to produce enough healthy red blood cells due to reduced kidney function


To keep you healthy, your kidneys are responsible for a lot of important functions such as balancing fluids, regulating blood pressure, producing certain hormones, and removing waste products from the blood.

CKD is defined as a gradual loss of kidney function, which is measured by your estimated glomerular filtration rate (eGFR). CKD is most often caused by diabetes and high blood pressure, but may also be caused by other factors.

Estimated glomerular filtration rate, or eGFR | A number based on your blood test for creatinine. It tells how well your kidneys are working.


Common in patients with CKD, anemia is a condition that happens when there aren't enough healthy red blood cells to carry the oxygen your body needs. To make healthy red blood cells, your body needs iron and erythropoietin (a hormone made by the kidneys).

Anemia in patients with CKD is often caused by iron deficiency, or not enough iron. This lack of iron may be caused by not having enough iron in your diet, not absorbing enough iron from your diet based on the foods you eat, or losing iron from blood loss.


Some common symptoms of iron deficiency anemia in CKD Some common symptoms of iron deficiency anemia in CKD

Please note, AURYXIA is not indicated to treat these symptoms.

Please note, many of the symptoms may have multiple causes beyond iron deficiency anemia.

Be sure to talk to your doctor if you are experiencing any symptoms so they can properly diagnose you.


Explore how AURYXIA
can help


Learn how and when you
should take AURYXIA

See Important Safety Information below


This information does not take the place of talking to your healthcare provider about your medical condition or treatment

What is the most important information I should know about AURYXIA®(ferric citrate)?

AURYXIA contains iron. Keep it away from children to prevent an accidental ingestion of iron and potentially fatal poisoning. Call a poison control center or your healthcare provider if a child swallows AURYXIA

AURYXIA can increase iron levels in your blood. Iron absorbed from AURYXIA may also increase iron in your body. Your healthcare provider will monitor your iron levels. If you are receiving intravenous (IV) iron, your IV iron dose may be adjusted or discontinued

What is AURYXIA?

AURYXIA is a prescription medicine that can lower the amount of phosphate in the blood for adults with chronic kidney disease (CKD) who ARE on dialysis

For adults who have iron deficiency anemia, as well as CKD, and are NOT on dialysis, AURYXIA is a prescription medicine that can increase hemoglobin levels and increase iron levels in the body

Who should not take AURYXIA?

Do not take AURYXIA if you have been diagnosed with an iron overload syndrome, such as hemochromatosis

AURYXIA may not be right for you. Before starting AURYXIA, tell your healthcare provider if you:

  • have any other medical conditions
  • are pregnant, plan to become pregnant, are breastfeeding or plan to breastfeed

Tell your healthcare provider about all of the medicines you take, including:

  • the antibiotics doxycycline or ciprofloxacin
  • prescription and over-the-counter medicines, vitamins, and herbal supplements

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist when you get a new medicine

How should I take AURYXIA?

  • Take AURYXIA exactly as prescribed by your healthcare provider
  • Take AURYXIA with meals and adhere to any diet prescribed by your healthcare provider
  • Your healthcare provider will tell you how much AURYXIA to take and may change your dose if necessary
  • Swallow AURYXIA whole. Do not chew or crush.
  • If you are taking the antibiotics doxycycline or ciprofloxacin, you will need to take it separately from AURYXIA. Follow your healthcare provider's instructions on when to take doxycycline or ciprofloxacin while you are also taking AURYXIA

What are the most common side effects of AURYXIA?

The most common side effects of AURYXIA for use in the treatment of iron deficiency anemia in adult patients with CKD not on dialysis include:

  • diarrhea
  • constipation
  • nausea
  • abdominal pain
  • high levels of potassium in the blood

AURYXIA contains iron and may cause dark stools, which are considered normal with oral medications containing iron

These are not all the side effects of AURYXIA. For more information ask your healthcare provider or pharmacist

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Call your healthcare provider for medical advice about side effects. You may report suspected side effects to Akebia Therapeutics, Inc. at 1-844-445-3799 or FDA at 1-800-FDA-1088 or

How should I store AURYXIA?

  • Store AURYXIA between 68 to 77°F (20 to 25°C)
  • Keep AURYXIA tablets dry

For more information see full Prescribing Information or call 1-844-445-3799